Sandbox Reserved 709

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Template:Sandbox ESBS 2012

Image:2c1m.png

Template:STRUCTURE 2c1m

Contents

NUP50:IMPORTIN-ALPHA COMPLEX

Template:ABSTRACT PUBMED 16222336

About this Structure

2c1m is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

See Also

IMPORTIN ALPHA STRUCTURE

Importin α is a soluble adaptor protein also known as karyopherin α. It has as a function to connect importin β and a protein which have a cNLS (classical Nuclear Localization Signal) in order to import this protein in the nucleus. A NLS is a basic residue-rich sequence with the following consensus sequence :

  • Two adjacent basic amino acids (Arg or Lys).
  • A spacer region of any 10 residues.
  • At least three basic residues (Arg or Lys) in the five positions after the spacer region.


Reference

  • Matsuura Y, Stewart M. Nup50/Npap60 function in nuclear protein import complex disassembly and importin recycling. EMBO J. 2005 Nov 2;24(21):3681-9. Epub 2005 Oct 13. PMID:16222336
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