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1sfc

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Template:STRUCTURE 1sfc

Contents

NEURONAL SYNAPTIC FUSION COMPLEX

Template:ABSTRACT PUBMED 9759724

Function

[SNP25_RAT] t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. [VAMP2_RAT] Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). [STX1A_RAT] Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.

About this Structure

1sfc is a 12 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  • Sutton RB, Fasshauer D, Jahn R, Brunger AT. Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution. Nature. 1998 Sep 24;395(6700):347-53. PMID:9759724 doi:http://dx.doi.org/10.1038/26412

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