2a3y

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Template:STRUCTURE 2a3y

Contents

Pentameric crystal structure of human serum amyloid P-component bound to Bis-1,2-{[(Z)-2carboxy-2-methyl-1,3-dioxane]-5-yloxycarbamoyl}-ethane.

Template:ABSTRACT PUBMED 16036920

Disease

[SAMP_HUMAN] Note=SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.

Function

[SAMP_HUMAN] Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.

About this Structure

2a3y is a 5 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Ho JG, Kitov PI, Paszkiewicz E, Sadowska J, Bundle DR, Ng KK. Ligand-assisted aggregation of proteins. Dimerization of serum amyloid P component by bivalent ligands. J Biol Chem. 2005 Sep 9;280(36):31999-2008. Epub 2005 Jul 20. PMID:16036920 doi:10.1074/jbc.M504403200

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