2k7l

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Template:STRUCTURE 2k7l

Contents

NMR structure of a complex formed by the C-terminal domain of human RAP74 and a phosphorylated peptide from the central domain of the FCP1

Template:ABSTRACT PUBMED 19215094

Function

[T2FA_HUMAN] TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.[1]

About this Structure

2k7l is a 2 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  • Yang A, Abbott KL, Desjardins A, Di Lello P, Omichinski JG, Legault P. NMR structure of a complex formed by the carboxyl-terminal domain of human RAP74 and a phosphorylated peptide from the central domain of the FCP1 phosphatase. Biochemistry. 2009 Mar 10;48(9):1964-74. PMID:19215094 doi:10.1021/bi801549m
  1. ↑ Rossignol M, Keriel A, Staub A, Egly JM. Kinase activity and phosphorylation of the largest subunit of TFIIF transcription factor. J Biol Chem. 1999 Aug 6;274(32):22387-92. PMID:10428810

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