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2h63
From Proteopedia
Contents |
Crystal Structure of Human Biliverdin Reductase A (CASP Target)
Disease
[BIEA_HUMAN] Defects in BLVRA are the cause of hyperbiliverdinemia (HBLVD) [MIM:614156]. HBLVD is a condition characterized by a green discoloration of the skin, urine, serum, and other bodily fluids. It is due to increased biliverdin resulting from inefficient conversion to bilirubin. Affected individuals appear to have symptoms only in the context of obstructive cholestasis and/or liver failure. In some cases, green jaundice can resolve after resolution of obstructive cholestasis.
Function
[BIEA_HUMAN] Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.
About this Structure
2h63 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Categories: Biliverdin reductase | Homo sapiens | Arrowsmith, C. | Bunkoczi, G. | Delft, F von. | Edwards, A. | Elkins, J. | Guo, K. | Kavanagh, K. | Lukacik, P. | Oppermann, U. | Papagrigoriou, E. | Pilka, E. | SGC, Structural Genomics Consortium. | Smee, C. | Sundstrom, M. | Ugochukwu, E. | Weigelt, J. | Blvra | Oxidoreductase | Sgc | Structural genomic | Structural genomics consortium
