Structural highlights
Evolutionary Conservation
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Publication Abstract from PubMed
We demonstrate a fragment-based lead discovery method that combines site-directed ligand discovery with dynamic combinatorial chemistry. Our technique targets dynamic combinatorial screening to a specified region of a protein by using reversible disulfide chemistry. We have used this technology to rapidly identify inhibitors of the drug target Aurora A that span the purine-binding site and the adaptive pocket of the kinase. The binding mode of a noncovalent inhibitor has been further characterized through crystallography.
Discovery of an Aurora kinase inhibitor through site-specific dynamic combinatorial chemistry.,Cancilla MT, He MM, Viswanathan N, Simmons RL, Taylor M, Fung AD, Cao K, Erlanson DA Bioorg Med Chem Lett. 2008 Jul 15;18(14):3978-81. Epub 2008 Jun 10. PMID:18579375[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Cancilla MT, He MM, Viswanathan N, Simmons RL, Taylor M, Fung AD, Cao K, Erlanson DA. Discovery of an Aurora kinase inhibitor through site-specific dynamic combinatorial chemistry. Bioorg Med Chem Lett. 2008 Jul 15;18(14):3978-81. Epub 2008 Jun 10. PMID:18579375 doi:10.1016/j.bmcl.2008.06.011
