Structural highlights
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The gamma-aminobutyric acid type A (GABA(A)) receptor-associated protein is a versatile adaptor protein playing an important role in intracellular vesicle trafficking, particularly in neuronal cells. We present the X-ray structure of the soluble form of human GABA(A) receptor-associated protein complexed with a high-affinity synthetic peptide at 1.3 A resolution. The data shed light on the probable binding modes of key interaction partners, including the GABA(A) receptor and the cysteine protease Atg4. The resulting models provide a structural background for further investigation of the unique biological properties of this protein.
Ligand binding mode of GABAA receptor-associated protein.,Weiergraber OH, Stangler T, Thielmann Y, Mohrluder J, Wiesehan K, Willbold D J Mol Biol. 2008 Sep 19;381(5):1320-31. Epub 2008 Jul 7. PMID:18638487[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Weiergraber OH, Stangler T, Thielmann Y, Mohrluder J, Wiesehan K, Willbold D. Ligand binding mode of GABAA receptor-associated protein. J Mol Biol. 2008 Sep 19;381(5):1320-31. Epub 2008 Jul 7. PMID:18638487 doi:10.1016/j.jmb.2008.06.086
