1yho

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PDB ID 1yho

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Ligands: and
Activity: Dihydrofolate reductase, with EC number 1.5.1.3
Coordinates: save as pdb, mmCIF, xml



Solution structure of human dihydrofolate reductase complexed with trimethoprim and nadph, 25 structures


Disease

Known disease associated with this structure: Anemia, megaloblastic, due to DHFR deficiency (1) OMIM:[126060]

About this Structure

1YHO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Solution structure of human dihydrofolate reductase in its complex with trimethoprim and NADPH., Kovalevskaya NV, Smurnyy YD, Polshakov VI, Birdsall B, Bradbury AF, Frenkiel T, Feeney J, J Biomol NMR. 2005 Sep;33(1):69-72. PMID:16222560

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