3e17

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Template:STRUCTURE 3e17

Contents

Crystal structure of the second PDZ domain from human Zona Occludens-2

Template:ABSTRACT PUBMED 19342771

Disease

[ZO2_HUMAN] Defects in TJP2 are involved in familial hypercholanemia (FHCA) [MIM:607748]. FHCA is a disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption.[1]

Function

[ZO2_HUMAN] Plays a role in tight junctions and adherens junctions.

About this Structure

3e17 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Chen H, Tong S, Li X, Wu J, Zhu Z, Niu L, Teng M. Structure of the second PDZ domain from human zonula occludens 2. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Apr 1;65(Pt, 4):327-30. Epub 2009 Mar 25. PMID:19342771 doi:10.1107/S1744309109002334
  1. ↑ Carlton VE, Harris BZ, Puffenberger EG, Batta AK, Knisely AS, Robinson DL, Strauss KA, Shneider BL, Lim WA, Salen G, Morton DH, Bull LN. Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT. Nat Genet. 2003 May;34(1):91-6. PMID:12704386 doi:10.1038/ng1147

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