2lou

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Template:STRUCTURE 2lou

Contents

AR55 solubilised in DPC micelles

Template:ABSTRACT PUBMED 23438363

Function

[APJ_HUMAN] Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.

About this Structure

2lou is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  • Langelaan DN, Reddy T, Banks AW, Dellaire G, Dupre DJ, Rainey JK. Structural features of the apelin receptor N-terminal tail and first transmembrane segment implicated in ligand binding and receptor trafficking. Biochim Biophys Acta. 2013 Jun;1828(6):1471-83. doi:, 10.1016/j.bbamem.2013.02.005. Epub 2013 Feb 22. PMID:23438363 doi:10.1016/j.bbamem.2013.02.005

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OCA

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