4han

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Template:STRUCTURE 4han

Contents

Crystal structure of Galectin 8 with NDP52 peptide

Template:ABSTRACT PUBMED 23511477

Function

[LEG8_HUMAN] Lectin with a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans.[1] [CACO2_HUMAN] May play a role in ruffle formation and actin cytoskeleton organization. Seems to negatively regulate constitutive secretion.[2]

About this Structure

4han is a 4 chain structure with sequence from Alfaropsis roxburghiana and Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Ideo H, Matsuzaka T, Nonaka T, Seko A, Yamashita K. Galectin-8-N-domain recognition mechanism for sialylated and sulfated glycans. J Biol Chem. 2011 Apr 1;286(13):11346-55. Epub 2011 Feb 2. PMID:21288902 doi:10.1074/jbc.M110.195925
  2. ↑ Morriswood B, Ryzhakov G, Puri C, Arden SD, Roberts R, Dendrou C, Kendrick-Jones J, Buss F. T6BP and NDP52 are myosin VI binding partners with potential roles in cytokine signalling and cell adhesion. J Cell Sci. 2007 Aug 1;120(Pt 15):2574-85. Epub 2007 Jul 17. PMID:17635994 doi:jcs.007005

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