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3zm5
From Proteopedia
Contents |
CRYSTAL STRUCTURE OF MURF LIGASE IN COMPLEX WITH CYANOTHIOPHENE INHIBITOR
Template:ABSTRACT PUBMED 23786712
Function
[Q8DNV6_STRR6] Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity).[RuleBase:RU004136]
About this Structure
3zm5 is a 1 chain structure with sequence from Streptococcus pneumoniae r6. Full crystallographic information is available from OCA.
Reference
- Hrast M, Turk S, Sosic I, Knez D, Randall CP, Barreteau H, Contreras-Martel C, Dessen A, O'Neill AJ, Mengin-Lecreulx D, Blanot D, Gobec S. Structure-activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF. Eur J Med Chem. 2013 May 21;66C:32-45. doi: 10.1016/j.ejmech.2013.05.013. PMID:23786712 doi:10.1016/j.ejmech.2013.05.013
Categories: Streptococcus pneumoniae r6 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | Barreteau, H. | Blanot, D. | Contreras-Martel, C. | Dessen, A. | Gobec, S. | Hrast, M. | Knez, D. | Mengin-Lecreulx, D. | ONeill, A J. | Randall, C P. | Sosic, I. | Turk, S. | Adp-forming enzyme | Atp-binding | Cell cycle | Cell divison | Cell shape | Cell wall | Ligase | Nucleotide-binding | Peptidoglycan synthesis
