This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4f3k
From Proteopedia
Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with homocysteine-DADMe-Immucillin-A
Function
[E8NLP5_SALET] Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity).[HAMAP-Rule:MF_01684]
About this Structure
4f3k is a 2 chain structure with sequence from Salmonella enterica subsp. enterica serovar choleraesuis str. scsa50. Full crystallographic information is available from OCA.
Categories: Adenosylhomocysteine nucleosidase | Salmonella enterica subsp. enterica serovar choleraesuis str. scsa50 | Almo, S C. | Bonanno, J B. | Haapalainen, A M. | Schramm, V L. | Thomas, K. | 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidase | Acting on glycosyl bond | Adenosylhomocysteine nucleosidase activity | Hydrolase activity | Hydrolase-hydrolase inhibitor complex | L-methionine biosynthetic process from s-adenosylmethionine | L-methionine salvage from methylthioadenosine | Methylthioadenosine nucleosidase activity
