4hwb

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Template:STRUCTURE 4hwb

Contents 1 Crystal structure of ectodomain 3 of the IL-13 receptor alpha 1 in complex with a human neutralizing monoclonal antibody fragment 2 Function 3 About this Structure 4 Reference

Crystal structure of ectodomain 3 of the IL-13 receptor alpha 1 in complex with a human neutralizing monoclonal antibody fragment

Template:ABSTRACT PUBMED 23384096

Function

[I13R1_HUMAN] Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.

About this Structure

4hwb is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Redpath NT, Xu Y, Wilson NJ, Andrews AE, Fabri LJ, Baca M, Braley H, Lu P, Ireland C, Ernst RE, Woods A, Forrest G, An Z, Zaller DM, Strohl WR, Luo CS, Czabotar PE, Garrett TP, Hilton DJ, Nash AD, Zhang JG, Nicola NA. Production of a human neutralizing monoclonal antibody and its crystal structure in complex with the ectodomain 3 of the interleukin-13 receptor alpha1. Biochem J. 2013 Feb 6. PMID:23384096 doi:10.1042/BJ20121819