4f2j
From Proteopedia
Contents |
Crystal structure of ZNF217 bound to DNA, P6522 crystal form
Template:ABSTRACT PUBMED 23436653
Function
[ZN217_HUMAN] Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'.[1] [2] [3] [4]
About this Structure
4f2j is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Vandevenne M, Jacques DA, Artuz C, Nguyen CD, Kwan AH, Segal DJ, Matthews JM, Crossley M, Guss JM, Mackay JP. New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217. J Biol Chem. 2013 Apr 12;288(15):10616-27. doi: 10.1074/jbc.M112.441451. Epub, 2013 Feb 22. PMID:23436653 doi:10.1074/jbc.M112.441451
- ↑ Huang G, Krig S, Kowbel D, Xu H, Hyun B, Volik S, Feuerstein B, Mills GB, Stokoe D, Yaswen P, Collins C. ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction. Hum Mol Genet. 2005 Nov 1;14(21):3219-25. Epub 2005 Oct 3. PMID:16203743 doi:10.1093/hmg/ddi352
- ↑ Krig SR, Jin VX, Bieda MC, O'Geen H, Yaswen P, Green R, Farnham PJ. Identification of genes directly regulated by the oncogene ZNF217 using chromatin immunoprecipitation (ChIP)-chip assays. J Biol Chem. 2007 Mar 30;282(13):9703-12. Epub 2007 Jan 26. PMID:17259635 doi:10.1074/jbc.M611752200
- ↑ Thillainadesan G, Isovic M, Loney E, Andrews J, Tini M, Torchia J. Genome analysis identifies the p15ink4b tumor suppressor as a direct target of the ZNF217/CoREST complex. Mol Cell Biol. 2008 Oct;28(19):6066-77. doi: 10.1128/MCB.00246-08. Epub 2008 Jul , 14. PMID:18625718 doi:10.1128/MCB.00246-08
- ↑ Quinlan KG, Nardini M, Verger A, Francescato P, Yaswen P, Corda D, Bolognesi M, Crossley M. Specific recognition of ZNF217 and other zinc finger proteins at a surface groove of C-terminal binding proteins. Mol Cell Biol. 2006 Nov;26(21):8159-72. Epub 2006 Aug 28. PMID:16940172 doi:10.1128/MCB.00680-06
