3h15

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Template:STRUCTURE 3h15

Contents

Crystal structure of replication initiation factor MCM10-ID bound to ssDNA

Template:ABSTRACT PUBMED 19608746

Function

[MCM10_XENLA] Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication (By similarity).[1]

About this Structure

3h15 is a 2 chain structure with sequence from Xenopus laevis. Full crystallographic information is available from OCA.

Reference

  • Warren EM, Huang H, Fanning E, Chazin WJ, Eichman BF. Physical interactions between Mcm10, DNA, and DNA polymerase alpha. J Biol Chem. 2009 Sep 4;284(36):24662-72. Epub 2009 Jul 16. PMID:19608746 doi:10.1074/jbc.M109.020438
  1. ↑ Wohlschlegel JA, Dhar SK, Prokhorova TA, Dutta A, Walter JC. Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45. Mol Cell. 2002 Feb;9(2):233-40. PMID:11864598

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