2osl

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spinqualitylabelsall models PDB ID 2osl Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
2osl, resolution 2.60Å ()
Structural annotation: Resources: InterPro : Ipr003006, Ipr003597, Ipr013783, Ipr007110, Ipr013106, Ipr003596 Pfam : PF07686, PF07654 UniProt : Q6PJA4, Q6PIH7, P11836
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Contents 1 Crystal structure of Rituximab Fab in complex with an epitope peptide 2 Disease 3 Function 4 About this Structure 5 See Also 6 Reference

Crystal structure of Rituximab Fab in complex with an epitope peptide

Template:ABSTRACT PUBMED 17395584

Disease

[CD20_HUMAN] Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5) [MIM:613495]; also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.^[1]

Function

[CD20_HUMAN] This protein may be involved in the regulation of B-cell activation and proliferation.

About this Structure

2osl is a 6 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

See Also

• Antibody
• Monoclonal Antibody
• Rituximab

Reference

• Du J, Wang H, Zhong C, Peng B, Zhang M, Li B, Huo S, Guo Y, Ding J. Structural basis for recognition of CD20 by therapeutic antibody Rituximab. J Biol Chem. 2007 May 18;282(20):15073-80. Epub 2007 Mar 29. PMID:17395584 doi:10.1074/jbc.M701654200

1. ↑ Kuijpers TW, Bende RJ, Baars PA, Grummels A, Derks IA, Dolman KM, Beaumont T, Tedder TF, van Noesel CJ, Eldering E, van Lier RA. CD20 deficiency in humans results in impaired T cell-independent antibody responses. J Clin Invest. 2010 Jan;120(1):214-22. doi: 10.1172/JCI40231. Epub 2009 Dec 21. PMID:20038800 doi:10.1172/JCI40231