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1xed
From Proteopedia
Revision as of 19:54, 29 September 2014 by OCA (Talk | contribs)
1xed is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The polymeric immunoglobulin receptor (pIgR) is a type I transmembrane protein that delivers dimeric IgA (dIgA) and pentameric IgM to mucosal secretions. Here, we report the 1.9 A resolution X-ray crystal structure of the N-terminal domain of human pIgR, which binds dIgA in the absence of other pIgR domains with an equilibrium dissociation constant of 300 nM. The structure of pIgR domain 1 reveals a folding topology similar to immunoglobulin variable domains, but with differences in the counterparts of the complementarity determining regions (CDRs), including a helical turn in CDR1 and a CDR3 loop that points away from the other CDRs. The unusual CDR3 loop position prevents dimerization analogous to the pairing of antibody variable heavy and variable light domains. The pIgR domain 1 structure allows interpretation of previous mutagenesis results and structure-based comparisons between pIgR and other IgA receptors.
Crystal structure of a polymeric immunoglobulin binding fragment of the human polymeric immunoglobulin receptor.,Hamburger AE, West AP Jr, Bjorkman PJ Structure. 2004 Nov;12(11):1925-35. PMID:15530357[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
↑ Hamburger AE, West AP Jr, Bjorkman PJ. Crystal structure of a polymeric immunoglobulin binding fragment of the human polymeric immunoglobulin receptor. Structure. 2004 Nov;12(11):1925-35. PMID:15530357 doi:10.1016/j.str.2004.09.006
