3iql

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Template:STRUCTURE 3iql

Contents 1 Crystal structure of the rat endophilin-A1 SH3 domain 2 Function 3 About this Structure 4 Reference

Crystal structure of the rat endophilin-A1 SH3 domain

Template:ABSTRACT PUBMED 20064468

Function

[SH3G2_RAT] Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature.^[1][2]

About this Structure

3iql is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

• Trempe JF, Chen CX, Grenier K, Camacho EM, Kozlov G, McPherson PS, Gehring K, Fon EA. SH3 domains from a subset of BAR proteins define a Ubl-binding domain and implicate parkin in synaptic ubiquitination. Mol Cell. 2009 Dec 25;36(6):1034-47. PMID:20064468 doi:10.1016/j.molcel.2009.11.021

1. ↑ Farsad K, Ringstad N, Takei K, Floyd SR, Rose K, De Camilli P. Generation of high curvature membranes mediated by direct endophilin bilayer interactions. J Cell Biol. 2001 Oct 15;155(2):193-200. Epub 2001 Oct 15. PMID:11604418 doi:10.1083/jcb.200107075
2. ↑ Gallop JL, Jao CC, Kent HM, Butler PJ, Evans PR, Langen R, McMahon HT. Mechanism of endophilin N-BAR domain-mediated membrane curvature. EMBO J. 2006 Jun 21;25(12):2898-910. Epub 2006 Jun 8. PMID:16763559