3ano

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Template:STRUCTURE 3ano

Contents

Crystal Structure of a Novel Diadenosine 5',5-P1,P4-Tetraphosphate Phosphorylase from Mycobacterium tuberculosis H37Rv

Template:ABSTRACT PUBMED 21565198

Function

[AP4A_MYCTU] Catabolizes diadenosine 5',5-P1,P4-tetraphosphate (Ap4A) into ADP and ATP. It does not catalyze the reverse phosphorolysis reaction. The optimum substrates are dinucleoside polyphosphates containing four or five phosphate residues.[1] [2]

About this Structure

3ano is a 2 chain structure with sequence from Mycobacterium sp. h37rv. Full crystallographic information is available from OCA.

Reference

  • Mori S, Shibayama K, Wachino J, Arakawa Y. Structural insights into the novel diadenosine 5',5-P(1),P(4)-tetraphosphate phosphorylase from Mycobacterium tuberculosis H37Rv. J Mol Biol. 2011 Jul 1;410(1):93-104. doi: 10.1016/j.jmb.2011.04.059. Epub 2011, May 4. PMID:21565198 doi:http://dx.doi.org/10.1016/j.jmb.2011.04.059
  1. ↑ Mori S, Shibayama K, Wachino J, Arakawa Y. Purification and molecular characterization of a novel diadenosine 5',5-P(1),P(4)-tetraphosphate phosphorylase from Mycobacterium tuberculosis H37Rv. Protein Expr Purif. 2010 Jan;69(1):99-105. doi: 10.1016/j.pep.2009.09.010. Epub, 2009 Sep 22. PMID:19778616 doi:http://dx.doi.org/10.1016/j.pep.2009.09.010
  2. ↑ Mori S, Shibayama K, Wachino J, Arakawa Y. Structural insights into the novel diadenosine 5',5-P(1),P(4)-tetraphosphate phosphorylase from Mycobacterium tuberculosis H37Rv. J Mol Biol. 2011 Jul 1;410(1):93-104. doi: 10.1016/j.jmb.2011.04.059. Epub 2011, May 4. PMID:21565198 doi:http://dx.doi.org/10.1016/j.jmb.2011.04.059

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