3aqp

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Template:STRUCTURE 3aqp

Contents 1 Crystal structure of SecDF, a translocon-associated membrane protein, from Thermus thrmophilus 2 Function 3 About this Structure 4 Reference

Crystal structure of SecDF, a translocon-associated membrane protein, from Thermus thrmophilus

Template:ABSTRACT PUBMED 21562494

Function

[SECDF_THET8] Conducts protons, which can be regulated by a proton gradient or by binding of an unfolded protein. Proton conduction requires the large periplasmic domain of the SecD.[HAMAP-Rule:MF_01463_B] Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.[HAMAP-Rule:MF_01463_B]

About this Structure

3aqp is a 2 chain structure with sequence from Thet8. Full crystallographic information is available from OCA.

Reference

• Tsukazaki T, Mori H, Echizen Y, Ishitani R, Fukai S, Tanaka T, Perederina A, Vassylyev DG, Kohno T, Maturana AD, Ito K, Nureki O. Structure and function of a membrane component SecDF that enhances protein export. Nature. 2011 May 11;474(7350):235-8. doi: 10.1038/nature09980. PMID:21562494 doi:10.1038/nature09980