3ipd

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Template:STRUCTURE 3ipd

Contents 1 Helical extension of the neuronal SNARE complex into the membrane, spacegroup I 21 21 21 2 Function 3 About this Structure 4 Reference

Helical extension of the neuronal SNARE complex into the membrane, spacegroup I 21 21 21

Template:ABSTRACT PUBMED 19571812

Function

[SNP25_RAT] t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. [VAMP2_RAT] Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). [STX1A_RAT] Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.

About this Structure

3ipd is a 8 chain structure with sequence from Rattus norvegicus. This structure supersedes the now removed PDB entry 3hd9. Full crystallographic information is available from OCA.

Reference

• Stein A, Weber G, Wahl MC, Jahn R. Helical extension of the neuronal SNARE complex into the membrane. Nature. 2009 Jul 23;460(7254):525-8. Epub 2009 Jul 1. PMID:19571812 doi:10.1038/nature08156