4js8

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Template:STRUCTURE 4js8

Contents 1 Crystal structure of TTK kinase domain with an inhibitor: 401348 2 Function 3 About this Structure 4 Reference

Crystal structure of TTK kinase domain with an inhibitor: 401348

Function

[TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.^[1]

About this Structure

4js8 is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

1. ↑ Jelluma N, Brenkman AB, van den Broek NJ, Cruijsen CW, van Osch MH, Lens SM, Medema RH, Kops GJ. Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment. Cell. 2008 Jan 25;132(2):233-46. doi: 10.1016/j.cell.2007.11.046. PMID:18243099 doi:10.1016/j.cell.2007.11.046