4jw3

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Template:STRUCTURE 4jw3

Contents

Selection of specific protein binders for pre-defined targets from an optimized library of artificial helicoidal repeat proteins (alphaRep)

Template:ABSTRACT PUBMED 24014183

Function

[NCZS_STRML] NCS has antibiotic activity (for Gram-positive bacteria) and antitumor activity (for certain mouse tumors). NCS binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks.

About this Structure

4jw3 is a 4 chain structure with sequence from Gekko coi and Streptomyces malayensis. Full crystallographic information is available from OCA.

Reference

  • Guellouz A, Valerio-Lepiniec M, Urvoas A, Chevrel A, Graille M, Fourati-Kammoun Z, Desmadril M, van Tilbeurgh H, Minard P. Selection of Specific Protein Binders for Pre-Defined Targets from an Optimized Library of Artificial Helicoidal Repeat Proteins (alphaRep). PLoS One. 2013 Aug 27;8(8):e71512. doi: 10.1371/journal.pone.0071512. PMID:24014183 doi:10.1371/journal.pone.0071512

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