3w3x

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Template:STRUCTURE 3w3x

Contents

Crystal structure of Kap121p bound to Pho4p

Template:ABSTRACT PUBMED 23541588

Function

[IMB3_YEAST] Involved in the nuclear import of ribosomal proteins. Binds to nucleoporins and the GTP-bound form of GSP1 (Ran). Plays a role in protein secretion. [PHO4_YEAST] Transcriptional activator that regulates the expression of repressible phosphatase under phosphate starvation conditions. Binds to the upstream activating sequence (UAS) of several phosphatase encoding PHO genes. Inhibited by the cyclin-CDK PHO80-PHO85 under high-phosphate conditions.

About this Structure

3w3x is a 2 chain structure with sequence from Atcc 18824. Full crystallographic information is available from OCA.

Reference

  • Kobayashi J, Matsuura Y. Structural basis for cell-cycle dependent nuclear import mediated by the karyopherin Kap121p. J Mol Biol. 2013 Mar 27. pii: S0022-2836(13)00194-0. doi:, 10.1016/j.jmb.2013.02.035. PMID:23541588 doi:http://dx.doi.org/10.1016/j.jmb.2013.02.035

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