2yn0

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Template:STRUCTURE 2yn0

Contents

tau55 histidine phosphatase domain

Template:ABSTRACT PUBMED 23569204

Function

[TFC7_YEAST] TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and similar genes.[1]

About this Structure

2yn0 is a 1 chain structure with sequence from Saccharomyces cerevisiae s288c. Full crystallographic information is available from OCA.

Reference

  • Taylor NM, Glatt S, Hennrich ML, von Scheven G, Grotsch H, Fernandez-Tornero C, Rybin V, Gavin AC, Kolb P, Muller CW. Structural and functional characterization of a phosphatase domain within yeast general transcription factor TFIIIC. J Biol Chem. 2013 Apr 8. PMID:23569204 doi:10.1074/jbc.M112.427856
  1. ↑ Manaud N, Arrebola R, Buffin-Meyer B, Lefebvre O, Voss H, Riva M, Conesa C, Sentenac A. A chimeric subunit of yeast transcription factor IIIC forms a subcomplex with tau95. Mol Cell Biol. 1998 Jun;18(6):3191-200. PMID:9584160

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