4ibx

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Template:STRUCTURE 4ibx

Contents

Crystal structure of stabilized TEM-1 beta-lactamase variant v.13

Template:ABSTRACT PUBMED 23542341

Function

[BLAT_ECOLX] TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.

About this Structure

4ibx is a 5 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

  • Dellus-Gur E, Toth-Petroczy A, Elias M, Tawfik DS. What Makes a Protein Fold Amenable to Functional Innovation? Fold Polarity and Stability Trade-offs. J Mol Biol. 2013 Mar 28. pii: S0022-2836(13)00200-3. doi:, 10.1016/j.jmb.2013.03.033. PMID:23542341 doi:10.1016/j.jmb.2013.03.033

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