4bh5

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Template:STRUCTURE 4bh5

Contents 1 LytM domain of EnvC, an activator of cell wall amidases in Escherichia coli 2 Function 3 About this Structure 4 Reference

LytM domain of EnvC, an activator of cell wall amidases in Escherichia coli

Template:ABSTRACT PUBMED 23796240

Function

[ENVC_ECOLI] Activator of the cell wall hydrolases AmiA and AmiB. Required for septal murein cleavage and daughter cell separation during cell division. In vitro, exhibits weak endoproteolytic activity on beta-casein.^{[1] [2] [3] [4]}

About this Structure

4bh5 is a 4 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.

Reference

• Peters NT, Morlot C, Yang DC, Uehara T, Vernet T, Bernhardt TG. Structure-function analysis of the LytM domain of EnvC, an activator of cell wall remodeling at the Escherichia coli division site. Mol Microbiol. 2013 Jun 25. doi: 10.1111/mmi.12304. PMID:23796240 doi:10.1111/mmi.12304

1. ↑ Ichimura T, Yamazoe M, Maeda M, Wada C, Hiraga S. Proteolytic activity of YibP protein in Escherichia coli. J Bacteriol. 2002 May;184(10):2595-602. PMID:11976287
2. ↑ Bernhardt TG, de Boer PA. Screening for synthetic lethal mutants in Escherichia coli and identification of EnvC (YibP) as a periplasmic septal ring factor with murein hydrolase activity. Mol Microbiol. 2004 Jun;52(5):1255-69. PMID:15165230 doi:10.1111/j.1365-2958.2004.04063.x
3. ↑ Uehara T, Dinh T, Bernhardt TG. LytM-domain factors are required for daughter cell separation and rapid ampicillin-induced lysis in Escherichia coli. J Bacteriol. 2009 Aug;191(16):5094-107. doi: 10.1128/JB.00505-09. Epub 2009 Jun, 12. PMID:19525345 doi:10.1128/JB.00505-09
4. ↑ Uehara T, Parzych KR, Dinh T, Bernhardt TG. Daughter cell separation is controlled by cytokinetic ring-activated cell wall hydrolysis. EMBO J. 2010 Apr 21;29(8):1412-22. doi: 10.1038/emboj.2010.36. Epub 2010 Mar 18. PMID:20300061 doi:10.1038/emboj.2010.36