4bhb

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Template:STRUCTURE 4bhb

Contents

Crystal structure of Mycobacterium tuberculosis O6-METHYLGUANINE METHYLTRANSFERASE

Template:ABSTRACT PUBMED 23564173

Function

[OGT_MYCTU] Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated (By similarity).

About this Structure

4bhb is a 1 chain structure with sequence from Mycobacterium tuberculosis h37rv. Full crystallographic information is available from OCA.

Reference

  • Miggiano R, Casazza V, Garavaglia S, Ciaramella M, Perugino G, Rizzi M, Rossi F. BIOCHEMICAL AND STRUCTURAL STUDIES ON THE M. TUBERCULOSIS O6-METHYLGUANINE METHYLTRANSFERASE AND MUTATED VARIANTS. J Bacteriol. 2013 Apr 5. PMID:23564173 doi:10.1128/JB.02298-12

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