4k00

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Template:STRUCTURE 4k00

Contents

Crystal structure of Slr0204, a 1,4-dihydroxy-2-naphthoyl-CoA thioesterase from Synechocystis

Template:ABSTRACT PUBMED 24100308

Function

[DNCH_SYNY3] Catalyzes the specific hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in phylloquinone (vitamin K1) biosynthesis. Is not active on benzoyl-CoA, phenylacetyl-CoA and aliphatic acyl-CoA thioesters.[1]

About this Structure

4k00 is a 2 chain structure with sequence from Syny3. Full crystallographic information is available from OCA.

Reference

  • Furt F, Allen WJ, Widhalm JR, Madzelan P, Rizzo RC, Basset G, Wilson MA. Functional convergence of structurally distinct thioesterases from cyanobacteria and plants involved in phylloquinone biosynthesis. Acta Crystallogr D Biol Crystallogr. 2013 Oct;69(Pt 10):1876-88. doi:, 10.1107/S0907444913015771. Epub 2013 Sep 20. PMID:24100308 doi:http://dx.doi.org/10.1107/S0907444913015771
  1. ↑ Widhalm JR, van Oostende C, Furt F, Basset GJ. A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5599-603. doi:, 10.1073/pnas.0900738106. Epub 2009 Mar 25. PMID:19321747 doi:10.1073/pnas.0900738106

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