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4bh9

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Template:STRUCTURE 4bh9

Contents

A structural model of CAP mutant (T127L and S128I) in the apo state

Function

[CRP_ECOLI] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.[1]

About this Structure

4bh9 is a 1 chain structure with sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

  1. ↑ Aiba H. Transcription of the Escherichia coli adenylate cyclase gene is negatively regulated by cAMP-cAMP receptor protein. J Biol Chem. 1985 Mar 10;260(5):3063-70. PMID:2982847

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