4bez

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Template:STRUCTURE 4bez

Contents 1 Night blindness causing G90D rhodopsin in the active conformation 2 Function 3 About this Structure 4 Reference

Night blindness causing G90D rhodopsin in the active conformation

Template:ABSTRACT PUBMED 23579341

Function

[OPSD_BOVIN] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).^{[1] [2]}

About this Structure

4bez is a 1 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

• Singhal A, Ostermaier MK, Vishnivetskiy SA, Panneels V, Homan KT, Tesmer JJ, Veprintsev D, Deupi X, Gurevich VV, Schertler GF, Standfuss J. Insights into congenital stationary night blindness based on the structure of G90D rhodopsin. EMBO Rep. 2013 Apr 12. doi: 10.1038/embor.2013.44. PMID:23579341 doi:10.1038/embor.2013.44

1. ↑ Nakamichi H, Okada T. Local peptide movement in the photoreaction intermediate of rhodopsin. Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12729-34. Epub 2006 Aug 14. PMID:16908857
2. ↑ Salom D, Lodowski DT, Stenkamp RE, Le Trong I, Golczak M, Jastrzebska B, Harris T, Ballesteros JA, Palczewski K. Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16123-8. Epub 2006 Oct 23. PMID:17060607