2fbe

From Proteopedia

Revision as of 14:50, 20 March 2008 by OCA (Talk | contribs)
Jump to: navigation, search
Image:2fbe.gif


PDB ID 2fbe

Drag the structure with the mouse to rotate
, resolution 2.52Å
Gene: gene 19q13.4.1 (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of the PRYSPRY-domain


Overview

We determined the first structure of PRYSPRY, a domain found in over 500 different proteins, involved in innate immune signaling, cytokine signaling suppression, development, cell growth and retroviral restriction. The fold encompasses a 7-stranded and a 6-stranded antiparallel beta-sheet, arranged in a beta-sandwich. In the crystal, PRYSPRY forms a dimer where the C-terminus of an acceptor molecule binds to the concave surface of a donor molecule, which represents a putative interaction site. Mutations in the PRYSPRY domains of Pyrin, which are responsible for familial Mediterranean fever, map on the putative PRYSPRY interaction site.

About this Structure

2FBE is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the PRYSPRY-domain: implications for autoinflammatory diseases., Grutter C, Briand C, Capitani G, Mittl PR, Papin S, Tschopp J, Grutter MG, FEBS Lett. 2006 Jan 9;580(1):99-106. Epub 2005 Dec 9. PMID:16364311

Page seeded by OCA on Thu Mar 20 16:50:20 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2fbe"
Personal tools