4k30

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Template:STRUCTURE 4k30

Contents 1 Structure of the N-acetyltransferase domain of human N-acetylglutamate synthase 2 Disease 3 Function 4 About this Structure 5 Reference

Structure of the N-acetyltransferase domain of human N-acetylglutamate synthase

Template:ABSTRACT PUBMED 23894642

Disease

[NAGS_HUMAN] Hyperammonemia due to N-acetylglutamate synthetase deficiency. The disease is caused by mutations affecting the gene represented in this entry.

Function

[NAGS_HUMAN] Plays a role in the regulation of ureagenesis by producing variable amounts of N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPSI) activity.

About this Structure

4k30 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Zhao G, Jin Z, Allewell NM, Tuchman M, Shi D. Crystal structure of the N-acetyltransferase domain of human N-acetyl-L-glutamate synthase in complex with N-acetyl-L-glutamate provides insights into its catalytic and regulatory mechanisms. PLoS One. 2013 Jul 24;8(7):e70369. doi: 10.1371/journal.pone.0070369. Print 2013. PMID:23894642 doi:10.1371/journal.pone.0070369