4k74

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Template:STRUCTURE 4k74

Contents 1 The UmuC subunit of the E. coli DNA polymerase V shows a unique interaction with the beta-clamp processivity factor. 2 Function 3 About this Structure 4 Reference

The UmuC subunit of the E. coli DNA polymerase V shows a unique interaction with the beta-clamp processivity factor.

Template:ABSTRACT PUBMED 23822808

Function

[Q1R4N6_ECOUT] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA (By similarity).[PIRNR:PIRNR000804]

About this Structure

4k74 is a 4 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

• Patoli AA, Winter JA, Bunting KA. The UmuC subunit of the E. coli DNA polymerase V shows a unique interaction with the beta-clamp processivity factor. BMC Struct Biol. 2013 Jul 4;13(1):12. PMID:23822808 doi:10.1186/1472-6807-13-12