3oit

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Template:STRUCTURE 3oit

Contents

Crystal structure of curcuminoid synthase CUS from Oryza sativa

Function

[CUS_ORYSJ] Plant-specific type III polyketide synthase (PKS) that catalyzes the one-pot formation of the C6-C7-C6 diarylheptanoid scaffold of bisdemethoxycurcumin by the condensation of two molecules of 4-coumaroyl-CoA and one molecule of malonyl-CoA.[1]

About this Structure

3oit is a 2 chain structure with sequence from Japanese rice. Full crystallographic information is available from OCA.

Reference

  • Miyazono K, Um J, Imai FL, Katsuyama Y, Ohnishi Y, Horinouchi S, Tanokura M. Crystal structure of curcuminoid synthase CUS from Oryza sativa. Proteins. 2011 Feb;79(2):669-73. doi: 10.1002/prot.22888. PMID:21117241 doi:http://dx.doi.org/10.1002/prot.22888
  1. ↑ Morita H, Wanibuchi K, Nii H, Kato R, Sugio S, Abe I. Structural basis for the one-pot formation of the diarylheptanoid scaffold by curcuminoid synthase from Oryza sativa. Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19778-83. Epub 2010 Nov 1. PMID:21041675 doi:http://dx.doi.org/10.1073/pnas.1011499107

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