4axl

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Template:STRUCTURE 4axl

Contents 1 HUMAN CATHEPSIN L APO FORM WITH ZN 2 Function 3 About this Structure 4 Reference

HUMAN CATHEPSIN L APO FORM WITH ZN

Template:ABSTRACT PUBMED 23658062

Function

[CATL1_HUMAN] Important for the overall degradation of proteins in lysosomes.

About this Structure

4axl is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Ehmke V, Winkler E, Banner DW, Haap W, Schweizer WB, Rottmann M, Kaiser M, Freymond C, Schirmeister T, Diederich F. Optimization of Triazine Nitriles as Rhodesain Inhibitors: Structure-Activity Relationships, Bioisosteric Imidazopyridine Nitriles, and X-ray Crystal Structure Analysis with Human Cathepsin L. ChemMedChem. 2013 Jun;8(6):967-75. doi: 10.1002/cmdc.201300112. Epub 2013 May 9. PMID:23658062 doi:10.1002/cmdc.201300112