Structural highlights
Publication Abstract from PubMed
Determination of a macromolecular structure using x-ray diffraction is a multistep process that involves a plethora of techniques involving molecular biology, bioinformatics, and physical sciences. Counterintuitively, the success of any or all individual steps does not guarantee the success of the overall process. This review examines the difficulties presented by each step on the path from a gene to the final publication, together with certain lucky (or unlucky) circumstances that can affect the velocity along that path.
Determination of protein structures--a series of fortunate events.,Chruszcz M, Wlodawer A, Minor W Biophys J. 2008 Jul;95(1):1-9. Epub 2008 Apr 25. PMID:18441029[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Chruszcz M, Wlodawer A, Minor W. Determination of protein structures--a series of fortunate events. Biophys J. 2008 Jul;95(1):1-9. Epub 2008 Apr 25. PMID:18441029 doi:10.1529/biophysj.108.131789
