4gmp
From Proteopedia
Contents |
Crystal structure of enterovirus 71 strain 1095 procapsid
Template:ABSTRACT PUBMED 23637404
Function
[E5RPG0_9ENTO] Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).[SAAS:SAAS001676_004_016611] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266] RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS001676_004_010047]
About this Structure
4gmp is a 2 chain structure with sequence from Human enterovirus 71. Full crystallographic information is available from OCA.
Reference
- Cifuente JO, Lee H, Yoder JD, Shingler KL, Carnegie MS, Yoder JL, Ashley RE, Makhov AM, Conway JF, Hafenstein S. The EV71 strain 1095 structures of procapsid and mature virion. J Virol. 2013 May 1. PMID:23637404 doi:10.1128/JVI.03519-12
