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3znf

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Template:STRUCTURE 3znf

Contents

HIGH-RESOLUTION THREE-DIMENSIONAL STRUCTURE OF A SINGLE ZINC FINGER FROM A HUMAN ENHANCER BINDING PROTEIN IN SOLUTION

Template:ABSTRACT PUBMED 2248949

Function

[ZEP1_HUMAN] This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis.[:][1] [2] [3]

About this Structure

3znf is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  • Omichinski JG, Clore GM, Appella E, Sakaguchi K, Gronenborn AM. High-resolution three-dimensional structure of a single zinc finger from a human enhancer binding protein in solution. Biochemistry. 1990 Oct 9;29(40):9324-34. PMID:2248949
  1. ↑ Muchardt C, Seeler JS, Nirula A, Shurland DL, Gaynor RB. Regulation of human immunodeficiency virus enhancer function by PRDII-BF1 and c-rel gene products. J Virol. 1992 Jan;66(1):244-50. PMID:1727488
  2. ↑ Seeler JS, Muchardt C, Suessle A, Gaynor RB. Transcription factor PRDII-BF1 activates human immunodeficiency virus type 1 gene expression. J Virol. 1994 Feb;68(2):1002-9. PMID:8289330
  3. ↑ Lallemand C, Palmieri M, Blanchard B, Meritet JF, Tovey MG. GAAP-1: a transcriptional activator of p53 and IRF-1 possesses pro-apoptotic activity. EMBO Rep. 2002 Feb;3(2):153-8. Epub 2002 Jan 29. PMID:11818340 doi:10.1093/embo-reports/kvf032

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