4bqm

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Template:STRUCTURE 4bqm

Contents

Crystal structure of human liver-type glutaminase, catalytic domain

Function

[GLSL_HUMAN] Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.[1]

About this Structure

4bqm is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Hu W, Zhang C, Wu R, Sun Y, Levine A, Feng Z. Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7455-60. doi:, 10.1073/pnas.1001006107. Epub 2010 Apr 8. PMID:20378837 doi:10.1073/pnas.1001006107

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