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4eck

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Template:STRUCTURE 4eck

Contents

Crystal Structure of the Toxoplasma gondii TS-DHFR

Template:ABSTRACT PUBMED 24053355

Function

[DRTS_TOXGO] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity).

About this Structure

4eck is a 2 chain structure with sequence from Toxoplasma gondii. Full crystallographic information is available from OCA.

Reference

  • Sharma H, Landau MJ, Vargo MA, Spasov KA, Anderson KS. First Three-Dimensional Structure of Toxoplasma gondii thymidylate synthase-dihydrofolate reductase: Insights for Catalysis, Interdomain Interactions, and Substrate Channeling. Biochemistry. 2013 Sep 20. PMID:24053355 doi:10.1021/bi400576t

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OCA

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