This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4kc3

From Proteopedia

Revision as of 07:39, 28 August 2013 by OCA (Talk | contribs)
Jump to: navigation, search

Template:STRUCTURE 4kc3

Contents

Cytokine/receptor binary complex

Function

[IL33_HUMAN] Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Acts as a chemoattractant tor Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury.[1] [2] [3] [4] [5] [6] [7] In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or proinflammatory activation.[8] [9] [10] [11] [12] [13] [14] [ILRL1_HUMAN] Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.[15]

About this Structure

4kc3 is a 2 chain structure with sequence from Homo sapiens and Rhizobium loessense. Full crystallographic information is available from OCA.

Reference

  1. ↑ Schmitz J, Owyang A, Oldham E, Song Y, Murphy E, McClanahan TK, Zurawski G, Moshrefi M, Qin J, Li X, Gorman DM, Bazan JF, Kastelein RA. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity. 2005 Nov;23(5):479-90. PMID:16286016 doi:S1074-7613(05)00311-0
  2. ↑ Komai-Koma M, Xu D, Li Y, McKenzie AN, McInnes IB, Liew FY. IL-33 is a chemoattractant for human Th2 cells. Eur J Immunol. 2007 Oct;37(10):2779-86. PMID:17853410 doi:10.1002/eji.200737547
  3. ↑ Carriere V, Roussel L, Ortega N, Lacorre DA, Americh L, Aguilar L, Bouche G, Girard JP. IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo. Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):282-7. Epub 2006 Dec 21. PMID:17185418 doi:10.1073/pnas.0606854104
  4. ↑ Kuchler AM, Pollheimer J, Balogh J, Sponheim J, Manley L, Sorensen DR, De Angelis PM, Scott H, Haraldsen G. Nuclear interleukin-33 is generally expressed in resting endothelium but rapidly lost upon angiogenic or proinflammatory activation. Am J Pathol. 2008 Oct;173(4):1229-42. doi: 10.2353/ajpath.2008.080014. Epub 2008 , Sep 11. PMID:18787100 doi:10.2353/ajpath.2008.080014
  5. ↑ Moussion C, Ortega N, Girard JP. The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'? PLoS One. 2008 Oct 6;3(10):e3331. doi: 10.1371/journal.pone.0003331. PMID:18836528 doi:10.1371/journal.pone.0003331
  6. ↑ Ali S, Mohs A, Thomas M, Klare J, Ross R, Schmitz ML, Martin MU. The dual function cytokine IL-33 interacts with the transcription factor NF-kappaB to dampen NF-kappaB-stimulated gene transcription. J Immunol. 2011 Aug 15;187(4):1609-16. doi: 10.4049/jimmunol.1003080. Epub 2011, Jul 6. PMID:21734074 doi:10.4049/jimmunol.1003080
  7. ↑ Kakkar R, Hei H, Dobner S, Lee RT. Interleukin 33 as a mechanically responsive cytokine secreted by living cells. J Biol Chem. 2012 Feb 24;287(9):6941-8. doi: 10.1074/jbc.M111.298703. Epub 2012, Jan 3. PMID:22215666 doi:10.1074/jbc.M111.298703
  8. ↑ Schmitz J, Owyang A, Oldham E, Song Y, Murphy E, McClanahan TK, Zurawski G, Moshrefi M, Qin J, Li X, Gorman DM, Bazan JF, Kastelein RA. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity. 2005 Nov;23(5):479-90. PMID:16286016 doi:S1074-7613(05)00311-0
  9. ↑ Komai-Koma M, Xu D, Li Y, McKenzie AN, McInnes IB, Liew FY. IL-33 is a chemoattractant for human Th2 cells. Eur J Immunol. 2007 Oct;37(10):2779-86. PMID:17853410 doi:10.1002/eji.200737547
  10. ↑ Carriere V, Roussel L, Ortega N, Lacorre DA, Americh L, Aguilar L, Bouche G, Girard JP. IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo. Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):282-7. Epub 2006 Dec 21. PMID:17185418 doi:10.1073/pnas.0606854104
  11. ↑ Kuchler AM, Pollheimer J, Balogh J, Sponheim J, Manley L, Sorensen DR, De Angelis PM, Scott H, Haraldsen G. Nuclear interleukin-33 is generally expressed in resting endothelium but rapidly lost upon angiogenic or proinflammatory activation. Am J Pathol. 2008 Oct;173(4):1229-42. doi: 10.2353/ajpath.2008.080014. Epub 2008 , Sep 11. PMID:18787100 doi:10.2353/ajpath.2008.080014
  12. ↑ Moussion C, Ortega N, Girard JP. The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'? PLoS One. 2008 Oct 6;3(10):e3331. doi: 10.1371/journal.pone.0003331. PMID:18836528 doi:10.1371/journal.pone.0003331
  13. ↑ Ali S, Mohs A, Thomas M, Klare J, Ross R, Schmitz ML, Martin MU. The dual function cytokine IL-33 interacts with the transcription factor NF-kappaB to dampen NF-kappaB-stimulated gene transcription. J Immunol. 2011 Aug 15;187(4):1609-16. doi: 10.4049/jimmunol.1003080. Epub 2011, Jul 6. PMID:21734074 doi:10.4049/jimmunol.1003080
  14. ↑ Kakkar R, Hei H, Dobner S, Lee RT. Interleukin 33 as a mechanically responsive cytokine secreted by living cells. J Biol Chem. 2012 Feb 24;287(9):6941-8. doi: 10.1074/jbc.M111.298703. Epub 2012, Jan 3. PMID:22215666 doi:10.1074/jbc.M111.298703
  15. ↑ Schmitz J, Owyang A, Oldham E, Song Y, Murphy E, McClanahan TK, Zurawski G, Moshrefi M, Qin J, Li X, Gorman DM, Bazan JF, Kastelein RA. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity. 2005 Nov;23(5):479-90. PMID:16286016 doi:S1074-7613(05)00311-0

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4kc3"
Personal tools