4ky8

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Template:STRUCTURE 4ky8

Contents 1 Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, methotrexate, FdUMP and 4-((2-amino-6-methyl-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)thio)-2-chlorophenyl)-L-glutamic acid 2 Function 3 About this Structure 4 Reference

Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, methotrexate, FdUMP and 4-((2-amino-6-methyl-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)thio)-2-chlorophenyl)-L-glutamic acid

Template:ABSTRACT PUBMED 23927969

Function

[Q5CGA3_CRYHO] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity).[PIRNR:PIRNR000389]

About this Structure

4ky8 is a 5 chain structure with sequence from Cryptosporidium hominis. Full crystallographic information is available from OCA.

Reference

• Kumar VP, Frey KM, Wang Y, Jain HK, Gangjee A, Anderson KS. Substituted pyrrolo[2,3-d]pyrimidines as Cryptosporidium hominis thymidylate synthase inhibitors. Bioorg Med Chem Lett. 2013 Jul 24. pii: S0960-894X(13)00882-2. doi:, 10.1016/j.bmcl.2013.07.037. PMID:23927969 doi:10.1016/j.bmcl.2013.07.037