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4gh8

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Revision as of 12:30, 3 July 2013 by OCA (Talk | contribs)
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Template:STRUCTURE 4gh8

Contents

Crystal structure of a 'humanized' E. coli dihydrofolate reductase

Template:ABSTRACT PUBMED 23733948

Function

[DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

About this Structure

4gh8 is a 2 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.

Reference

  • Liu CT, Hanoian P, French JB, Pringle TH, Hammes-Schiffer S, Benkovic SJ. Functional significance of evolving protein sequence in dihydrofolate reductase from bacteria to humans. Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10159-64. doi:, 10.1073/pnas.1307130110. Epub 2013 Jun 3. PMID:23733948 doi:10.1073/pnas.1307130110

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OCA

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