Structural highlights
Publication Abstract from PubMed
Pyrococcus furiosus PF2050 is an uncharacterized putative protein that contains two DUF2666 domains. Functional and structural studies of PF2050 have not previously been performed. In this study, we determined the crystal structure of PF2050. The structure of PF2050 showed that the two DUF2666 domains interact tightly, forming a globular structure. Each DUF2666 domain comprises an antiparallel beta-sheet and an alpha-helical bundle. One side of the PF2050 structure has a positively charged basic cleft, which may have a DNA-binding function. Furthermore, we confirmed that PF2050 interacts with circular and linear dsDNA.
Crystal structure of Pyrococcus furiosus PF2050, a member of the DUF2666 protein family.,Han BG, Jeong KC, Cho JW, Jeong BC, Song HK, Lee JY, Shin DH, Lee S, Lee BI FEBS Lett. 2012 May 7;586(9):1384-8. doi: 10.1016/j.febslet.2012.04.004. Epub, 2012 Apr 13. PMID:22616997[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Han BG, Jeong KC, Cho JW, Jeong BC, Song HK, Lee JY, Shin DH, Lee S, Lee BI. Crystal structure of Pyrococcus furiosus PF2050, a member of the DUF2666 protein family. FEBS Lett. 2012 May 7;586(9):1384-8. doi: 10.1016/j.febslet.2012.04.004. Epub, 2012 Apr 13. PMID:22616997 doi:10.1016/j.febslet.2012.04.004
