4bpj

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Template:STRUCTURE 4bpj

Contents

Mcl-1 bound to alpha beta Puma BH3 peptide 3

Template:ABSTRACT PUBMED 23929624

Function

[MCL1_MOUSE] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis.

About this Structure

4bpj is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Smith BJ, Lee EF, Checco JW, Evangelista M, Gellman SH, Fairlie WD. Structure-guided rational design of alpha/beta-peptide foldamers with high affinity for BCL-2 family prosurvival proteins. Chembiochem. 2013 Sep 2;14(13):1564-72. doi: 10.1002/cbic.201300351. Epub 2013, Aug 8. PMID:23929624 doi:http://dx.doi.org/10.1002/cbic.201300351

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OCA

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