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4bvn

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Template:STRUCTURE 4bvn

Contents

Ultra-thermostable beta1-adrenoceptor with cyanopindolol bound

Template:ABSTRACT PUBMED 24663151

Function

[ADRB1_MELGA] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.

About this Structure

4bvn is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Miller-Gallacher JL, Nehme R, Warne T, Edwards PC, Schertler GF, Leslie AG, Tate CG. The 2.1 A Resolution Structure of Cyanopindolol-Bound beta1-Adrenoceptor Identifies an Intramembrane Na+ Ion that Stabilises the Ligand-Free Receptor. PLoS One. 2014 Mar 24;9(3):e92727. doi: 10.1371/journal.pone.0092727. eCollection, 2014. PMID:24663151 doi:http://dx.doi.org/10.1371/journal.pone.0092727

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OCA

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