4bxs

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Template:STRUCTURE 4bxs

Contents

Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis

Template:ABSTRACT PUBMED 23869089

Function

[FA5V_PSETE] Snake prothrombin activator that attacks the hemostatic system of prey. This non-catalytic subunit is functionally similar to blood coagulation factor V. It serves as a critical cofactor for the prothrombinase activity of the catalytic subunit, which is similar to the blood coagulation factor X.[1]

About this Structure

4bxs is a 2 chain structure with sequence from Pseudonaja textilis. Full crystallographic information is available from OCA.

Reference

  • Lechtenberg BC, Murray-Rust TA, Johnson DJ, Adams TE, Krishnaswamy S, Camire RM, Huntington JA. Crystal structure of the prothrombinase complex from the venom of Pseudonaja textilis. Blood. 2013 Jul 18. PMID:23869089 doi:10.1182/blood-2013-06-511733
  1. ↑ Rao VS, Kini RM. Pseutarin C, a prothrombin activator from Pseudonaja textilis venom: its structural and functional similarity to mammalian coagulation factor Xa-Va complex. Thromb Haemost. 2002 Oct;88(4):611-9. PMID:12362232 doi:10.1267/th02100611

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