4jph

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Template:STRUCTURE 4jph

Contents

Crystal structure of Protein Related to DAN and Cerberus (PRDC)

Template:ABSTRACT PUBMED 23850456

Function

[GREM2_MOUSE] Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner. Antagonized BMP4-induced suppression of progesterone production in granulosa cells.[1]

About this Structure

4jph is a 4 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Nolan K, Kattamuri C, Luedeke DM, Deng X, Jagpal A, Zhang F, Linhardt RJ, Kenny AP, Zorn AM, Thompson TB. Structure of Protein Related to Dan and Cerberus: Insights into the Mechanism of Bone Morphogenetic Protein Antagonism. Structure. 2013 Jul 9. pii: S0969-2126(13)00206-2. doi:, 10.1016/j.str.2013.06.005. PMID:23850456 doi:10.1016/j.str.2013.06.005
  1. ↑ Sudo S, Avsian-Kretchmer O, Wang LS, Hsueh AJ. Protein related to DAN and cerberus is a bone morphogenetic protein antagonist that participates in ovarian paracrine regulation. J Biol Chem. 2004 May 28;279(22):23134-41. Epub 2004 Mar 23. PMID:15039429 doi:10.1074/jbc.M402376200

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